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Angiotensin II Type 1 Receptor Blockers
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D047228 |
[Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.
] |
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Angiotensin II Type 2 Receptor Blockers
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D057912 |
[Agents that antagonize the ANGIOTENSIN II TYPE 2 RECEPTOR.
] |
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Angiotensin III
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D000805 |
[A heptapeptide formed from ANGIOTENSIN II after the removal of an amino acid at the N-terminal by AMINOPEPTIDASE A. Angiotensin III has the same efficacy as ANGIOTENSIN II in promoting ALDOSTERONE secretion and modifying renal blood flow, but less vasopressor activity (about 40%).
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Angiotensin Receptor Antagonists
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D057911 |
[Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR.
] |
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Angiotensin-Converting Enzyme 2
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D000085962 |
[A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.
] |
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Angiotensin-Converting Enzyme Inhibitors
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D000806 |
[A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
] |
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Angiotensinogen
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D000808 |
[A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities.
, An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
] |
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Angiotensins
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D000809 |
[Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANGIOTENSIN SYSTEM. These include angiotensins derived naturally from precursor ANGIOTENSINOGEN, and those synthesized.
] |
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Angola
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D000810 |
[A republic in southern Africa, southwest of DEMOCRATIC REPUBLIC OF THE CONGO and west of ZAMBIA. Its capital is Luanda.
] |
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Anguilla
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D000811 |
[A genus in the Family Anguillidae, Order Anguilliformes, that includes fresh water eels.
] |
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Anhedonia
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D059445 |
[Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).
] |
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Anhydrides
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D000812 |
[Chemical compounds derived from acids by the elimination of a molecule of water.
] |
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Anidulafungin
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D000077612 |
[Echinocandin antifungal agent that is used in the treatment of CANDIDEMIA and CANDIDIASIS.
] |
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Anilides
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D000813 |
[Any aromatic amide obtained by acylation of aniline.
] |
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Aniline Compounds
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D000814 |
[Compounds that include the aminobenzene structure.
] |
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Aniline Hydroxylase
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D000815 |
[A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.
] |
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Aniline Mustard
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D000816 |
[Alkylating anti-neoplastic agent.
] |
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Anilino Naphthalenesulfonates
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D000817 |
[A class of organic compounds which contain an anilino (phenylamino) group linked to a salt or ester of naphthalenesulfonic acid. They are frequently used as fluorescent dyes and sulfhydryl reagents.
] |
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Animal Assisted Therapy
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D056447 |
[The use of live animal as a means of therapy
] |
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Animal Care Committees
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D035661 |
[Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
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