A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.

Synonyms: Cyclic Nucleotide Phosphodiesterase PDE3 Family cGMP Inhibited Phosphodiesterase Cyclic Nucleotide Phosphodiesterases, Type 3 cGMP-Inhibited Phosphodiesterase Phosphodiesterase, cGMP-Inhibited Cyclic Nucleotide Phosphodiesterases, Type 3B Phosphodiesterase 3B Phosphodiesterase III Phosphodiesterase 3A Cyclic Nucleotide Phosphodiesterases, Type 3A 0 EC 3.1.4.17 cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase cGMP Inhibited Cyclic Nucleotide Phosphodiesterase