A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.

Synonyms: AT Mutated Protein EC 2.7.11.1 Mutated Protein, AT Protein, AT Mutated Protein, A-T A-T Protein Ataxia Telangiectasia Mutated Proteins A T Protein ATM Protein