A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. [ http://www.ncbi.nlm.nih.gov/pubmed/10102814 http://www.ncbi.nlm.nih.gov/pubmed/17986482 http://en.wikipedia.org/wiki/Mesenchymal_stem_cell http://flybase.org/reports/ma.htm http://www.ncbi.nlm.nih.gov/pubmed/16923606 http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/19960544 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613570 ]
Term information
- FMA:70546
- BTO:0003298
- BTO:0002625
cellxgene_subset
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
mesenchymal stem cell
mesenchymal progenitor cells
BMSC
mesenchymal stromal cells
mesenchymal precursor cell
stem cells, mesenchymal
CFU-F
mesenchymal stromal cell
MSC