A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive. [ http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/21220451 GOC:add http://www.ncbi.nlm.nih.gov/pubmed/11861604 http://en.wikipedia.org/wiki/B-1_cell http://www.ncbi.nlm.nih.gov/pubmed/20933013 GOC:dsd ]
Synonyms: B1 B-cell B-1 B-lymphocyte B-1 B lymphocyte B-1 B-cell B1 B lymphocyte B1 B cell B-1 cell B1 cell B1 B-lymphocyte
Term information
cellxgene_subset
There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low.
Term relations
- mature B cell and has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RABC and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has plasma membrane part some leukosialin and capable of some innate immune response and has high plasma membrane amount some IgM immunoglobulin complex
- mature B cell
- has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RABC
- has plasma membrane part some leukosialin
- has high plasma membrane amount some IgM immunoglobulin complex
- has plasma membrane part some membrane-spanning 4-domains subfamily A member 1
- capable of some innate immune response