A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles. [ https://www.worldcat.org/search?q=bn%3A0517223651 http://www.ncbi.nlm.nih.gov/pubmed/34772990 GOC:tfm https://orcid.org/0000-0002-0819-0473 http://www.ncbi.nlm.nih.gov/pubmed/34433485 ]
Synonyms: synovial fibroblast fibroblast-like synoviocyte
Term information
- FMA:66788
- BTO:0003652
Type B synovial cells play a key role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis, and are essential for the maintenance of normal joint functions. Fibroblast-like synoviocytes from different joints have different properties, which may contribute to the characteristic pattern of joint involvement in different types of arthritis.
Term relations
- stromal cell
- synovial cell
- produces some synovial fluid
- part of some synovial membrane of synovial joint
- capable of some hyaluronan biosynthetic process