A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. [ http://www.ncbi.nlm.nih.gov/pubmed/9826671 http://www.ncbi.nlm.nih.gov/pubmed/11756508 http://www.ncbi.nlm.nih.gov/pubmed/10704434 http://www.ncbi.nlm.nih.gov/pubmed/20142420 http://www.ncbi.nlm.nih.gov/pubmed/24133281 http://www.ncbi.nlm.nih.gov/pubmed/2182078 GOC:tfm ]
Term information
- MESH:D000073637
cellxgene_subset, human_reference_atlas
This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991).
oligodendrocyte/type-2 astrocyte progenitor cell
oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell