The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. [ GOC:add https://www.worldcat.org/search?q=bn%3A0781735149 ]
Synonyms: B-1 B-lymphocyte differentiation B-1 B lymphocyte differentiation B-1 B-cell differentiation