The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. [ GOC:dph GOC:tb GOC:sdb_2009 GOC:ebc ]
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- multicellular organismal process
- part of some keratinocyte differentiation
- occurs in some epidermal cell